Unveils how the immune system works and explores strategies for harnessing its potential for maintaining good health.

Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children.

This concise practical guide is designed to facilitate the clinical decision-making process in the management of atopic dermatitis by reviewing a number of cases and defining the various diagnostic and management decisions open to clinicians. It is well illustrated and diverse in scope, enabling the reader to obtain relevant information regarding both standard and unusual cases in a rapid, easy to digest format. Each case includes a narrative description and patient management tips along with a relevant board review question. This book covers exciting updates in the diagnosis and management of AD such atopic dermatitis spectrum disorder and the effects of internal vessel inflammation in AD patients. It also highlights the newest oral, biologic and topical therapies (along with pipeline therapies) in the treatment of atopic dermatitis.

This book provides an extensive exploration of current and future directions for understanding immunology, neuroscience, and the development of potent treatment modalities. It presents an in-depth analysis and expert commentary on the role of genetics, lifestyle factors, biomarkers, neuroimaging, cognitive domains, artificial intelligence, and innate immunity in MS pathogenesis

This book presents a comprehensive overview of sarcoidosis and related aspects. It discusses the cell signaling pathways and molecular mechanisms involved in sarcoidosis as well as pathophysiology, diagnosis, management, and treatment of the disease.

This textbook for graduate veterinary students provides basic concepts of veterinary immunopathology with particular reference to immunopathogenesis. The initial chapters provide up-to-date knowledge on important aspects of immunology, immunodeficiency disorders, hypersensitivity reactions, and autoimmune disorders of various animal species. The book examines different natural and synthetic immunomodulatory products that can modulate the immune system of animals. It discusses the immunopathogenesis and immunopathology of multiple diseases and immunopathological disorders in diverse animal species, including cattle, buffalo, sheep, goat, swine, equine, and laboratory animals. The book also covers the immunopathology of various body systems, including lungs, reproductive system, enteric system, mammary gland, joints, kidneys, and skin. It provides clinical manifestations that are useful in diagnosing immunopathological conditions. The book presents a highly informative text with high quality gross and microscopic photographs, diagrammatic presentations of immunopathological disorders and techniques, making it useful in both classrooms and professional training courses for students, researchers, and professionals alike.

Cancer treatment is a challenging issue, while the treatment modalities have extended from traditional surgery, chemotherapy, and radiation therapy to new therapeutic approaches, including targeted therapy, immunotherapy, stem cell transplantation, and hormone therapy. Therefore, an interdisciplinary approach is needed to find a better therapeutic protocols in order to increase the prognosis and quality of life of patients with cancer.

Hepatobiliary cancers, including hepatocellular carcinoma and biliary tract cancers, have high rate of mortality and low survival rate.