"Leishmaniases as Re-emerging Diseases" ed. by Farhat Afrin, Hassan Hemeg

This book gives a brief glimpse of the epidemiology of leishmaniasis, immune evasion, vaccination, and therapeutic modalities that may work by untangling the immunological cross-wires of pathogenic cross-talk. The Conventional treatment and its drawbacks, the prospects of phytotherapy and nanomedicines, are also discussed. The identification of drug targets with the aim of designing inhibitors is also exemplified.

Leishmania parasites plague the mammalian host causing high morbidity and mortality. The parasites persist in the hostile milieu, crippling its defensive arsenal. In the face of mounting resistance to an antiquated drug arsenal, new approaches are urgently desired to keep the infection at bay. Furthermore, to strengthen the leishmaniasis elimination drive, particular emphasis has to be laid on identification of new targets and vaccination strategies.

Contents
1. Leishmaniasis: An Emerging Clinical Syndrome
2. Visceral Leishmaniasis
3. Leishmaniases in West Africa: Past and Current
4. Immune Evasion Strategies
5. Vaccines for Human Leishmaniasis: Where Do We Stand and What Is Still Missing?
6. Vaccines for Visceral Leishmaniasis: Hopes and Hurdles
7. The Polyamine Pathway as a Potential Target for Leishmaniases Chemotherapy
8. 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGR) Enzyme of the Sterol Biosynthetic Pathway: A Potential Target against Visceral Leishmaniasis
9. Alternative Treatment for Leishmaniasis
10. Natural Compounds and Extracts from Mexican Medicinal Plants with Anti-Leishmanial Activity: An Update
11. Nanomedicines for Cutaneous Leishmaniasis
12. Crossing Biological Barriers for Leishmaniasis Therapy: From Nanomedicinal Targeting Perspective


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