Genome-Scale Algorithm Design (2nd Edition)
Genome-Scale Algorithm Design: Bioinformatics in the Era of High-Throughput Sequencing
English | 2023 | ISBN: 1009341235 | 469 Pages | PDF | 7.4 MB
English | 2023 | ISBN: 1009341235 | 469 Pages | PDF | 7.4 MB
Presenting the fundamental algorithms and data structures that power bioinformatics workflows, this book covers a range of topics from the foundations of sequence analysis (alignments and hidden Markov models) to classical index structures (k-mer indexes, suffix arrays, and suffix trees), Burrows–Wheeler indexes, graph algorithms, network flows, and a number of advanced omics applications. The chapters feature numerous examples, algorithm visualizations, and exercises, providing graduate students, researchers, and practitioners with a powerful algorithmic toolkit for the applications of high-throughput sequencing. An accompanying website (www.genome-scale.info) offers supporting teaching material. The second edition strengthens the toolkit by covering minimizers and other advanced data structures and their use in emerging pangenomics approaches.