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More than seven years after the world has become a frozen wasteland, the remnants of humanity inhabit a gigantic, perpetually-moving train that circles the globe as class warfare, social injustice and the politics of survival play out.
An elite team of FBI profilers analyze the country's most twisted criminal minds, anticipating their next moves before they strike again. The Behavioral Analysis Unit's most experienced agent is David Rossi, a founding member of the BAU who returns to help the team solve new cases.
A rare condition — face blindness — gives an eccentric yet incredibly gifted neurologist a unique perspective on care, fueling his mission to change the way people see his patients. Alongside a team of brilliant young interns, he solves some of the world's most puzzling psychological cases while navigating the complicated relationships that come with the job.
A year after the death of his friend and partner Sherlock Holmes at the hands of Moriarty, Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders. However, he soon finds that his old life is not done with him yet.