A police officer patrols a Philadelphia neighborhood hard-hit by the opioid crisis. When a series of murders begins in the neighborhood, Mickey realizes that her personal history might be related to the case.

Lost in a world reclaimed by nature and overrun by mysterious creatures, Ethan, a young man with amnesia navigates the dangerous landscape in search of his lost love Emma. His journey takes an unexpected turn when he encounters Mae, a hardened and eccentric survivor. Together, Ethan and Mae face threats both human and otherwise before a fateful encounter with Kai unravels a secret that lies just beyond Ethan's fractured memory.