Schizophrenia Spectrum Disorders (SSD) manifest multidimensionally, presenting a syndromic nature with several symptomatic domains. These are driven by dynamic systemic biological changes that unfold over the course of the disease. Thus far, the diagnosis is solely based on symptoms, which may be rather subjective, moving research toward the search for SSD biomarkers. This book presents a summary of the main hypotheses that have evolved over time to explain the pathophysiology of SSD and that have driven the discovery of associated biomarkers: neurotrophic, neurotransmitter, neuroendocrine, immune-inflammatory, nitrosative/oxidative stress, metabolic, and gut microbiota-brain axis. The book shows the most relevant research carried out in the last twelve years to develop predictive, diagnostic, theranostic or transdiagnostic models based on these biomarkers using the receiver operating characteristic curve (ROC) analysis. Chapters also discuss how the literature has addressed the development and/or addition of new discriminatory biomarkers to achieve robust and successful results. The book is rounded out with a step-by-step explanation on how to work on the MetaboAnalyst platform, including the meaning of the chosen statistics and how to interpret them in the results obtained. This book is a useful resource for students and scientists involved in the discovery of biomarkers for psychiatric disorders and other diseases.

This book presents the latest synthetic protocols for the assembly of functionalized Cp ligands and their transition metal complexes. Cyclopentadienyl (Cp) complexes of transition metals belong to the most important classes of transition metal complexes with tightly bound ligands in the coordination sphere since their discovery in the middle of the last century. Even though they have been known for a long time, this field constantly evolves to deliver novel modified Cp ligands and complexes and to blossom into new fields of application. Beside the synthesis of ligands and metal complexes this book concentrates on novel and prospering fields of their application in organic synthesis.

This book reviews the latest developments and applications in the field of biosensing, providing readers with an update of the earlier, successful edition, Biosensing for the 21st Century. In this book, readers will find comprehensive key information on the advances and challenges in biorecognition elements and transduction principles, including examples of new materials and new methods. Ranging from engineering chimeric enzymes to the progress in electrochemical sensing of drugs, the book discusses the latest innovations in the field and thus, provides the reader with a profound overview. In the field of biological recognition the focus will be on switchable sensors by engineering new proteins, the development of Molecular Imprinted Polymers (MIPs) for proteins or even larger biological entities, the construction of complex nucleic acid – protein structures for affinity sensing and the application of whole microbes.

This book expands on evidence-based, person-centered dementia care practice by offering the therapeutic essentials of a novel grief-based therapy including trauma informed yoga practices, and Dementia Grief Therapy (DGT). This therapy transcends the dementia divide: us (non-diagnosed) and them (diagnosed). Using physical activity as a shared common space. It begins from the perspective of the person diagnosed with dementia or behavioral and psychological symptoms of dementia (BPSD) In this way, the reader comes to understand a therapeutic practice that acknowledges, validates and invites a whole mind-body grief integration process. At present, the concept of “dementia grief” objectifies the person diagnosed by focusing on grief for the person (as experienced and observed by others), rather than compassionately acknowledging the grief of the person.

This book is an introduction to wind turbine aerodynamics for professionals and students with a diverse range of backgrounds. It is a self-contained textbook that shows how to progress from the basics of fluid mechanics to modern wind turbine blade design. It presents the fundamentals of fluid dynamics and inflow conditions, as well as extensive information on theories describing the aerodynamics of wind turbines. After examining a number of related experiments, the book applies the lessons learned to blade design.

This book lays out a foundation and taxonomy for Behavioral Decision Analysis, featuring representative work across various domains. Traditional research in the domain of Decision Analysis has focused on the design and application of logically consistent tools to support decision makers during the process of structuring problem complexity, modeling uncertainty, generating predictions, eliciting preferences, and, ultimately, making better decisions. Two commonly held assumptions are that the decision maker’s cognitive belief system is fully accessible and that this system can be understood and formalized by trained analysts. However, in past years, an active line of research has emerged studying instances in which such assumptions may not hold. This book unites this community under the common theme of Behavioral Decision Analysis. The taxonomy used in this book categorizes research based on task focus (prediction or decision) and behavioral level (individual or group). Two theoretical lenses that lie at the interface between (1) normative and descriptive research, and (2) normative and prescriptive research are introduced. The book then proceeds to highlight representative works across the two lenses focused on individual and group-level decision making. Featuring various methodologies and applications, the book serves as a reference for researchers, students, and professionals across different disciplines with a common interest in Behavioral Decision Analysis.

This book is a tribute to Dr Joan Chapple CNZM FRACS, who qualified as New Zealand's first formally trained female plastic surgeon in the late 1950s and practised as a plastic and hand surgeon in Auckland, New Zealand for over 38 years. She was selected for surgical training by the late Sir William Manchester, who started the Middlemore Plastic Surgery Unit in December 1950.

The Covid-19 pandemic and current international circumstances have left many individuals feeling vulnerable, both economically and psychologically. At the same time, pressure is put on healthcare systems, particularly in Europe, resulting in doctor shortages, heavy workloads, and low salaries for healthcare workers. Patients are experiencing longer waiting lists, shorter visiting times, and emergency rooms that underestimate patients' clinical problems. As a result, episodes of self-violence and violence resulting from different causes are happening more frequently, also in hospitals.

The fifth addition of this classic text that focuses on the diabetic foot continues the tradition of the previous four editions. More specifically, it includes contributions from a distinguished panel of clinicians and researchers, who have either participated in previous editions or are new, who provide up-to-date information on the pathophysiology and management of diabetic foot ulceration.

Following the success of the previous edition, the second edition of Geriatrics Models of Care is the definitive resource for systems-based practice improvement for the care of older adults. Several new models of care have been published in the last eight years, new outcomes have emerged to better understand the impact of existing models, and with the rise of the Age-Friendly Health Systems movement, promoting organized efforts to prepare our health care settings for older individuals is of more importance than ever.

This book presents the current trends in deep learning-based object detection framework with a focus on logo detection tasks. It introduces a variety of approaches, including attention mechanisms and domain adaptation for logo detection, and describes recent advancement in object detection frameworks using deep learning. We offer solutions to the major problems such as the lack of training data and the domain-shift issues.

This extensively revised edition of this important textbook provides a practical approach to the use of nuclear cardiology for the general cardiologist. It is an adjunct to the existing literature in nuclear cardiology, providing a simple case-based approach to understanding the methodology, application and outcomes of the modality, and representing a pocket-sized compendium designed for a clinical cardiology audience. Nuclear cardiology procedures have been a mainstay in noninvasive testing for the diagnosis and risk stratification of coronary artery disease for many years. Although a mature field with a multitude of clinical applications, the advances in the technology and imaging procedures have been remarkable and important to document.

This volume uses advanced machine learning techniques to analyze government communication to evaluate policy effectiveness. The book develops policy effectiveness foundation models by cohorting historical budget policies with statistical models which are built on well reputed data sources including economic events, macroeconomic trends, and ratings and commerce terms from international institutions. By signal mining policies to the economic outcome patterns, the book aims to create a rich source of successful policy insights in terms of their effectiveness in bringing development to the poor and underserved communities to ensure the spread of wealth, social wellbeing, and standard of living to the common denomination of society rather than a selected quotient. Enabling academics and practitioners across disciplines to develop applications for effective policy interventions, this volume will be of interest to a wide audience including software engineers, data scientists, social scientists, economists, and agriculture practitioners.

This book celebrates and explores some philosophical issues raised by the work of Alan Weir, who is Professor Emeritus at the University of Glasgow, having previously held positions at the Universities of Oxford, Edinburgh and Queen’s, Belfast. In a number of areas, Weir has elaborated strikingly original views which involve a radical departure from the mainstream. These include formalism in the philosophy of mathematics, and as well as naïve set theory, with a universal set, and a naïve theory of truth. In contrast to other contemporary defenders of the latter two theories, Weir rejects dialetheism and accepts classical rules for the logical connectives. He avoids contradictions by restricting certain structural inference rules, specifically some generalized versions of transitivity. In addition, Weir has developed radical versions of naturalism and physicalism (partly informed by his work on Quine) and perceptual realism. This collection includes contributions by a distinguished group of philosophers on Weir’s philosophy, as well as a memoir and a new essay on the philosophy of mathematics by Weir himself.

This book shows how multiple developments have caused the world to move from “an information society” to a “dream society”. Ongoing social and technological forces are pushing us from a world of words, rationality, and truth into a world of images, performance, and make-belief. Rather than deny or reject this transformation, this book argues that one should understand and embrace it as waves of new futures that the world must strive to surf for fame and fun. As a political scientist and futurist, the author also offers hints of new goals and forms of governance fit for a dream society, as he demonstrates that all current systems are ineffective and dangerously obsolete. This book is of great interest to political philosophers, futures scientists, sociologists, and those interested in cultural studies.